Fig. 5
From: Genetic interaction networks mediate individual statin drug response in Saccharomyces cerevisiae
Topology analyses of augmented GINs identify betweenness bottleneck genes and functional uniqueness of GINs. a 3D plot of gene values calculated for closeness centrality, eigenvector centrality and betweenness centrality for the optimised four clusterings (α, β, γ, δ) of data in the augmented GINs file (Supplementary Table S6). b Deconvoluted driver genes with maximum betweenness centrality from atorvastatin, cerivastatin, hmg1Δ, hmg2Δ and arv1Δ queries in S288C, Y55, UWOPS87-2421 and YPS606. c Uniqueness values derived from Gene Ontology semantic analysis of driver genes using multiple topology measurements: TI (topology independent), CCC (closeness centrality cluster), ECC (eigenvector centrality cluster), BCC (betweenness centrality cluster), 3FCC (closeness, eigenvector and betweenness clusters combined). Shown here are uniqueness (a score that represents the negative of average semantic linearity of a GO term to all other terms), coverage (represented by size of the symbol) and associated statistical significance for each genetic background
