Fig. 4
From: Defining subpopulations of differential drug response to reveal novel target populations
Subpopulations of cell lines indicating differential response between docetaxel and selumetinib. a Tree diagram illustrating the segmentation process of 840 cell lines across cancer types into subpopulations based on their response to docetaxel and selumetinib. Branch colours distinguish subsets of subpopulations with darker colours indicating increasing number of cell lines in the subpopulation. b Scatter plot of subpopulations discovered through progressive segmentation based on average log(IC50) values. Dashed lines indicate 20th percentile of log(IC50) values for each drug. The KRAS mutation is enriched in five subpopulations exhibiting sensitivity to selumetinib and resistance to docetaxel, including subpopulation 60. The colours of the subpopulations correspond to the location of the subpopulation in the tree diagram. c Bar plot illustrating the difference in AUC values for each cell line. The orange bars highlight the cell lines within subpopulation 60. d Heatmap showing the percentage of each cancer type enriched within the cell lines in subpopulation 60. The bar plot illustrates the KRAS mutations within the cell lines that are highlighted in green
