Fig. 2

MiRNA-mediated disease–disease networks. Two network graphs of the top 300 disease–disease pairs (Supplementary Table 1) identified by mpDisNet and miRNA-overlap measure, respectively, are shown. a A disease–disease network derived from the miRNA-overlap measure. The edges of disease–disease pairs in (a) represent the similarity by the miRNA-overlap measure (Eq. 1) alone. The top 300 inferred disease–disease pairs connecting 146 diseases are illustrated. b A disease–disease network identified by mpDisNet. The edges of disease–disease pairs in (b) represent the similarity from mpDisNet. In this graph, mpDisNet predicts disease-disease relationships by the combined M1 (disease–miRNA–gene–gene–miRNA–disease) and M3 (disease–gene–gene–disease) meta-paths (see Fig. 1). Top 300 inferred disease–disease pairs connecting 61 diseases are illustrated. The node size denotes the degree. The color of nodes is encoded based on the pathobiological categories of diseases. This image is generated by Gephi (https://gephi.org)