Fig. 1
From: An omnidirectional visualization model of personalized gene regulatory networks
a Diagram of a standard genomic experiment under two levels of treatment, I and II. Transcriptomic profiles are monitored at key time points including one before treatment (t0) and those reflecting early (t1), middle (t2), and late stages (t3) of response after treatment. b Sample-specific visualization of idopNetworks reconstructed from the above genomic experiment, which describe how six genes co-regulate each other. Genes 1 and 2 are antagonistic in samples 1 and 2, but with different extents. These two genes are synergistic in sample N and altruistic in a predicted sample. The directional synergism of gene 5 to gene 1 is strong in samples 1 and N, but weak in sample 2. Because outgoing links are more than incoming links, gene 5 is a social gene in all samples, but the degree of its sociality is different across samples. Sample-specific networks can be compared between different treatment levels, signals (pre- vs. post-treatment), and times after the treatment
