Fig. 2: Exome characterization of U87MG and NSP.

a Variant distributions in U87MG and NSP. b SNPs that are common and unique across the TMZ sensitive (U87MG) and resistant (NSP) cells. c Chromosome-wide distribution of mutations. d Electron transport chain complexes and their associated mutations profiled using exome sequencing—blue fonts indicate mutations in U87MG, red fonts indicate mutations in NSP and pink fonts indicate mutations in both cell types. e Signaling network perturbations that play a key role in controlling metabolism. A blue cross indicates a mutation in U87MG, A red cross indicates mutation in NSP, size of the cross is scaled based on the number of mutations (either equal sizes or different).