Fig. 1: A schematic overview of our personalised approach as well as the combined method (a population-wide approach).
From: A personalised approach for identifying disease-relevant pathways in heterogeneous diseases
a Summary of the analyses performed and approaches used in this study as well as a depiction of the separate and joint models used for GP modelling in the analyses. Here, m is the number of case-control pairs. b A schematic illustration of identifying differentially expressed genes (DEGs) and significant pathways using the personalised approach and the combined method. In the personalised approach, the DEGs are identified independently for each case-control pair and summarized on a pathway-level, whereas in the combined method, DEGs are identified by comparing all cases to all controls.
