Fig. 4: Metrics for quantifying phenotypic plasticity for the case of single-edge perturbations.
From: Identifying inhibitors of epithelial–mesenchymal plasticity using a network topology-based approach
a Two definitions of plasticity: PS1 (top-right) is defined as the fraction of multi-stable parameter sets identified by RACIPE. PS2 (bottom) is calculated after ZEB and miR200 expression levels are used to classify steady states obtained from each parameter set (denoted by different colors) into Epithelial (E)—(high miR-200, low ZEB)/Hybrid (H)—(high miR-200, high ZEB)/Mesenchymal (M)—(low miR-200, high ZEB) phenotypes. Parameter sets are then characterized as monostable or multi-stable based on the phenotypic states they sample. PS2 is defined as the fraction of parameter sets giving rise to multiple phenotypes. b Scatter plot of PS1 vs. PS2 for different EMP networks - WT (colored red) and perturbed (colored blue; single-edge perturbed: edge deletion, edge nature change and edge additions) ones. Spearman correlation coefficients (ρ) are denoted; ***p < 0.001.
