Fig. 5: Communities and their properties.
We developed tools (available on github) to query a community for its characterization. a Prediction power of "Whole Blood'' communities, in F1 scores thresholded over 0.8. Most communities in "Whole Blood'' do not have prediction power for the remaining tissues. Notable exceptions include a 13-member community, which can predict multiple tissues, including "Brain Anterior cingulate'', "Small Intestine'', and "Colon Transverse''. b A 15-member community in the hippocampus is shown here as an example. An edge indicates Aij > 0.80 for genes i and j. The gene TNR, which is expressed primarily in the central nervous system and involved in its development, is connected via an edge to twelve member genes while HIP1R is connected to only one. c Enrichment analysis was performed on all communities to identify known biological processes. For example, the hippocampal community in b was found to be significantly enriched for Reactome pathways. p-value refers to raw p-value. Red line corresponds to the raw p < 0.05 threshold. Color gradient reflects the adjusted p-value. All Reactome pathways shown meet adjusted p < 0.05. d Heatmap displays the correlation values for the member genes of the community in b.
