Fig. 3: Debugging and extension steps in GEMs by Bosi et al.
From: Curating and comparing 114 strain-specific genome-scale metabolic models of Staphylococcus aureus

Not all the 64 SBML files downloaded from the supplement of Bosi et al. did directly pass the syntactic validation. In seven steps, the errors reported in the validity check were solved to receive valid SBML files. The valid files were then further extended with appropriate SBO terms for genes, species, and reactions. In a final step, annotations were added to the model using ModelPolisher69.