Fig. 6: Strain-specific model comparison based on gene sets.
From: Curating and comparing 114 strain-specific genome-scale metabolic models of Staphylococcus aureus
For all models occurring in at least three different resources, the gene content was compared strain-specifically. After unifying the gene identifiers to KEGG IDs, Venn diagrams were created comparing the gene content. The models from Bosi et al. have, on average, the highest gene content, explaining the large fraction of genes occurring only in these models. The models by Lee et al. and the Path2Models project seem more similar, which could be explained by the fact that both are curated based on the KEGG database. Although all models in one Venn diagram (and thus, one comparison) represent the same strain, the models have differences, indicating the influence of the reconstruction method on the final model content.
