Fig. 2: Signal termination in a CMC: kinase faster than phosphatase, phosphatase with higher affinity. | npj Systems Biology and Applications

Fig. 2: Signal termination in a CMC: kinase faster than phosphatase, phosphatase with higher affinity.

From: Frequency-preference response in covalent modification cycles under substrate sequestration conditions

Fig. 2

a Velocity of the kinase (E1) relative to that of the phosphatase (E2) and affinity of the phosphatase relative to that of the kinase (phosphatase parameters values as in Fig. 1b). In each plot, V1/V2 and Aff2/Aff1 are indicated in the left axis while Q (=Pmax/Pss) is indicated in the right axis. V1/V2 is plotted in green, Aff2/Aff1 in purple, and Q in black. The shadowed region over the plot indicates values of Q < 1.6 (no signal termination). b Velocity and affinity of the phosphatase relative to those of the kinase (kinase parameters as in Fig. 1b). Other details are as in a. Parameter values: a1 = 3.5; d1 = 1; k1 = 50; a2 = 0.3; d2 = 0.25; k2 = 0.25; E1T = 100; E2T = 100; ST = 35.

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