Fig. 3: Parameter space exploration.

a V₁/V₂–Aff₂/Aff₁ parameter space, b E_2T/S_T–E_1T/S_T parameter space. Both panels include the output of numerical simulations for 20,000 parameter sets in the selected ranges of variation. Each dot represents a single simulation output. Dots in purple correspond to outputs with signal termination, dots in cyan correspond to the parameter sets that satisfy Bluthgen’s conditions (see text), dots in black correspond to the parameter sets that satisfy Bluthgen’s conditions and signal termination. All the other simulation results are in yellow. Outputs lower than 0.1 were excluded from the analysis. Since E_1T and E_2T are not kept constant (as was the case in Fig. 2), V_i = k_iE_1T/K_mi with i = 1,2. c V₁/V₂–Aff₂/Aff₁ parameter space, but plotting only outputs with signal termination and magnifying the signal termination region. Each output is color and symbol coded according to the value of E_2T/S_T and E_1T/S_T, gray dots if E_2T/S_T and E_1T/S_T > 1, cyan stars if only E_2T/S_T > 1, yellow triangles if only E_1T/S_T > 1, green crosses if E_2T/S_T and E_1T/S_T < 1. d E_2T/S_T−E_1T/S_T parameter space, but plotting only outputs with signal termination and magnifying the signal termination region. Each output is color and symbol coded according to the value of V₁/V₂ and Aff₂/Aff₁, gray dots if V₁/V₂ and Aff_2/Aff₁ > 1, cyan stars if only V₁/V₂ > 1, yellow triangles if only Aff₂/Aff₁, green crosses if V₁/V₂ and Aff₂/Aff₁ < 1. Horizontal and vertical black lines over the plots indicate V₁ = V₂, Aff₂ = Aff₁, E_1T = S_T, E_2T = S_T, respectively. The characteristics of each distribution are captured in box plots giving the median (color line as central value), the 95% confidence interval of the median, the first and third quartiles (box), the 5th, and 95th percentiles (end of whiskers). Extra symbols in line with the box plots are outliers.