Fig. 5: Frequency-preference response in a CMC under periodic stimulation. | npj Systems Biology and Applications

Fig. 5: Frequency-preference response in a CMC under periodic stimulation.

From: Frequency-preference response in covalent modification cycles under substrate sequestration conditions

Fig. 5

a Representative time courses for adapted sinusoidal inputs ST (upper panels) with increasing frequencies and the corresponding outputs P (lower panels). For the three stimulation frequencies, the maximum reached by ST is 35, whereas the minimum depends on the frequency, being 17.72, 24.81, and 30.01, in the left, middle, and right panels, respectively. The CMC parameter values are those listed for Fig. 4a and the periods of stimulation are, 33.33, 15.15, 6 s in left, middle, and right panels, respectively, resulting in frequencies of 0.03, 0.066, and 0.167 Hz. b Frequency response results, measuring amplitude (left) and gain (right) as a function of the input frequency. The amplitude of the output is defined as the difference between the maximum and the minimum values of P. The gain is the ratio between the amplitude of the output and that of the input. The three examples in a are indicated over the plot (same color code). c Representative time courses for the input ST (upper panels) and the corresponding outputs P (lower panels), corresponding to an adapted train of square pulses stimulation. For the three stimulation frequencies, the maximum reached by ST is 35, whereas the minimum depends on the frequency, being 20.3, 27.61, and 31.85 in the left, middle and right panels, respectively. Parameter values and input frequencies are as in a. d Frequency response results, measuring amplitude (left) and gain (right) as a function of the input frequency. The three examples in c are indicated over the plot (same color code).

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