Fig. 3: Dynamical and statistical analyses of changes in coagulation factor concentrations over time.

a Heatmap of changes in concentrations of coagulation factors (CFs) for 252 trauma patients who survived 24 h, dataset 2, grouped by initial concentration (percent activity) at the beginning of time period, show that concentrations move toward an equilibrium over time. If the starting concentration of any of factors II, V, VII, VIII, IX, X, ATIII, and protein C is low then the concentration increases, and if the starting concentration is high then the concentration decreases. Numerical values in the cells indicate the mean change of CF in that group, and the cell color represents this mean ΔCF according to the color bar on the right. b Comparison between the mean of coagulation factor concentration changes in trauma patients who died after 6 h, dataset 3, to the mean of coagulation factor concentration changes in the 252 trauma patients of panel (a) who were alive after the first 24 h, dataset 2, at different time periods (from 0 to 6 h, from 6 to 12 h, and from 12 to 24 h). The bar value indicates the mean of each group, the error bar represents a 95% confidence interval, and the p-value significance is indicated above/below each bar (ns: not significant, p > 0.05; *p ≤ 0.05; **p ≤ 0.01; and ***p ≤ 0.001). This panel confirms that patients who recover have coagulation factor concentrations that move to an equilibrium, with the change in coagulation factor concentrations moving to zero.