Fig. 9: Our proposed GCM algorithm recommendations drive thrombin generation toward a normal region over time for eight trauma patient samples, validating the correctness and performance of the algorithm.

a Estimated CAT trajectory from coagulation factor measurements for eight trauma patients over 24 h. The black line shows the GCM algorithm-recommended patient-specific CAT trajectory at 24 h if following the personalized coagulation factor recommendations for each patient. All recommended trajectories are visible inside normal ranges. Following the GCM algorithm recommendations shows desirable improvements over actual treatment received by eight trauma patients, in both CAT properties that are quantitatively compared to the normal region criteria (Supplementary Fig. 12a and b), and coagulation factor concentrations (Supplementary Fig. 12c and d). b Illustrative estimated CAT trajectory [nM] from coagulation factor measurements for Trauma Patient 3 at different instances over the first 24 h following hospital admission. The black line shows the GCM algorithm-recommended patient-specific CAT trajectory compared to the red line representing the actual CAT. This shows how the GCM algorithm dynamically adjusts the recommendations based on the most recent coagulation factor concentration measurements to move the CAT toward the normal region. In all instances, the recommended CAT is inside the normal region, leading the patient’s thrombin generation toward normal.