Fig. 3: Transcriptional characterization and dependency analysis of KRAS dependent KRASwt cell lines.
From: Diffusion kernel-based predictive modeling of KRAS dependency in KRAS wild type cancer cell lines
a Differentially expressed genes in KRASwt dependent vs independent cell lines (n = 567). Positive values on the x-axis reflect higher expression in the dependent subgroup, correspondingly negative values reflect higher expression in the independent subgroup. b Overrepresentation analysis (Reactome) of genome wide CRISPR screen genes exhibiting a higher dependency in the KRASwt dependent subgroup (Wilcoxon–Mann–Whitney Test; ngenes = 1038). c Percentage of cell lines harboring at least one RAE (blue) or no RAE (purple) in KRASwt subgroup for KRAS dependent (left) and independent (right) cell lines. Absolute values are shown above each column. d, e Binary co-dependency network of RAE in KRASwt highlighting the heterogeneous distribution of RAE (Dependent cell lines (d), independent (e)). Number of co-dependencies shared between two genes is shown if there were more than two co-dependencies. Node size refers to the number of cell lines classified as dependent on the respective gene. Cell lines without RAE were not included in the figures.
