Fig. 7: Connections of molecules exhibiting similar temporal patterns.
a The distribution of absolute temporal pattern similarity (TPSMAbs) values among all molecules. The dashed line indicates the threshold of TPSMAbs at 0.6. The colours of the histogram bars correspond to the metabolic group (top left in part b). b Connections of molecules exhibiting similar temporal patterns. Molecules above the threshold (0.6 in part a) are connected. The colours of the molecules correspond to the metabolic group (top left). The colours of the lines indicate positive or negative TPSM values, and the thickness of the lines corresponds to the magnitude of TPSMAbs, whereby the thicker the line, the greater the value (top centre). Components (i–vii) are defined as a set of molecules that are not connected to any other molecule. Abbreviations for the molecules are follows: ester type Cho ester type cholesterol, HDL cholesterol high-density lipoprotein cholesterol, LDL cholesterol low-density lipoprotein cholesterol, cholesterol E ratio cholesterol ester ratio, BUN blood urea nitrogen, Glu glutamic acid. c Betweenness centrality for the molecules shown in part b.
