Fig. 8: The Four Features of Temporal Patterns That Characterize Individual Differences Among Molecules. | npj Systems Biology and Applications

Fig. 8: The Four Features of Temporal Patterns That Characterize Individual Differences Among Molecules.

From: Four features of temporal patterns characterize similarity among individuals and molecules by glucose ingestion in humans

Fig. 8

a The distribution of TPSI, TVRI, and degNormalized of all molecules. The colours of the dots correspond to the metabolic group (inset). The names of the 18 glucose-responsive molecules that showed a significant change after glucose ingestion (Supplementary Fig. 3) are labelled and their abbreviations are as follows: Cit citrulline, Cor cortisol, CRP C-peptide, FFA free fatty acids, GH growth hormone; Glu + TBM Glu + threo-beta-methylasparate, GIP gastric inhibitory polypeptide (active), Glc glucose, Glu glutamic acid, Ile isoleucine, Ins insulin, Ketone total ketone bodies, Leu leucine, Met methionine, Pyr pyruvate, TBA total bile acid, Tyr tyrosine, 4M2O 4-methyl-2-oxopentanoate. b Properties of temporal patterns. AUC is the area under the curve, TAUC1/2 is the time to reach half of AUC. c Connections of molecules showing significant correlation (q < 0.1). The colours of the molecules correspond to the metabolic group (middle right). The colours of the lines indicate a positive or negative correlation coefficient, and the thickness of lines corresponds to the magnitude of the correlation coefficient (middle right). Note that |correlation| is an absolute value of the correlation coefficient. The thicker the line, the greater the |correlation|. No pair of the molecules had a 0.8 < |correlation| ≤ 0.9.

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