Fig. 2: Study design.
The figure depicts the topological relationships among the drug module (green), the disease module (blue), and the side-effect module (red) for a drug to be removed from (panel A) or retained for (panel B) consideration. The zAC and zBC denote the z-score normalized network proximity between the targets of the drug (C) and the genes associated with the disease (A) and with the side-effect (B), respectively. ASBC is the adjusted similarity between the drug targets (C) and the side-effect-associated genes (B). In the bottom row, the ASBC value is not reported for drugs with zBC > −1.65 since they are removed independent of their ASBC values.
