Table 2 Receptors in ligand–receptor interactions in the colon and ileum.
From: Mapping the epithelial–immune cell interactome upon infection in the gut and the upper airways
Tissue | Direction | Number | Receptors |
|---|---|---|---|
Colon only | Upregulated | 0 | – |
Colon only | Downregulated | 63 | ITGA1,2,7,8,910, ITGB4,6,8, NOD2, LRP8, CD151, CD74, CD97, TGFBR1,2, SLC45A3, SLC16A, SORL1, VANGL1, FCGR2B, SIRPG, PRNP, LILRA3, PDE1A, GPC1, CFTR, PTGER1, CR1, NCSTN, AHR, COL17A1 |
Ileum only | Upregulated | 88 | MCAM, CYSLTR1/2, ACVR1/2B/L1/2 A, SLC5A11, SLC7A1, ENG, TNFRSF13B/13 C/10 C/17/10B/10D, LILRA4, CELSR3, ADGRL4, ADCY9, ACKR2/3/4, EDNRA, CCR3/6/8, CXCR1/2, EPHA10, KEL, CSF3R/2RA, EDNRB, BMPR2/R1A/R1B, SMO, AMHR2, GPR75, LPAR2, NPR3, ACKR1, IFNLR1, ST14, MRC2, CD79A, IGF2R, PTPRU, MSR1 |
Ileum only | Downregulated | 38 | TSPAN1, SCTR, KIR2DL4, KIR3DL1, GRM3, ADRB2, PTH2R, BDKRB2, GRIN2A, KLRC3, PLPP6, CRHR1, CLEC2D, GPR37, GPR37L1, ITGA2B, SCN4A, CDH2, PTPRB, AQP6, DSG2, KIR2DL1, KIR3DL3, MIP, KCNQ3, TRPC3, GRM4, SCARF1, RTN4RL1, GPC2, OPRM1 |
Colon and ileum | Upregulated | 38 | F2RL1, ITGAM/X, F3, CXCR3/4/5/6, CCR1/2/4/7/9, CX3CR1, XCR1, PTPRS, PIGR, GPR160, CELSR2, PPARG, CDH5, CD83, CDH11, SPHK1, TRADD |
Colon and ileum | Downregulated | 66 | TLR1/2/4/7, VIPR1, TNFRSF19, PLD2, PLSCR1/4, SORT1, HFE, GP6, KLRC1/2/4, KLRG1, PDE1B/1 C, PDIA3, CD1A/B, CD3D/G, CD247, ITGAE, ITGA4/6, ITGB7, LILRB2, NGFR, GJB2, LRP5/6, FPR3, LDLR, RYR1, APLP2, CELSR1, KCNN4, KCNQ1/5, GLP2R, ESR1/2, CANX, IL2RB, ASGR1, KIR2DL2/3, PTPRA, DYSF, TRPC1 |
