Table 3 Ligand–receptors in intercellular interactions in the colon and ileum.

From: Mapping the epithelial–immune cell interactome upon infection in the gut and the upper airways

Tissue

Direction

Number

Ligand–receptor interactions

Colon only

Upregulated

1

FAS _ RIPK1

Colon only

Downregulated

125

APP _ TNFRSF21, CD74, CCR5, SLC45A3, CAV1, NCSTN, FCGR2B, GPC1, LRP1, NGFR, ADRA2A

AREG _ LTK, CSF1R, MERTK, INSR, NTRK1/2/3, ROR1/2, PDGFRB, LMTK2, FLT3, PTK7, MET, TIE1, AATK, DDR2, MST1R, AXL, TYRO3, MUSK, RET, PDGFRA, RYK

CALM1 _ PDE1A

CALM2 _ PDE1A

CALM3 _ MYLK, GP6, KCNQ1/5, PDE1A/B/C, INSR, ESR1/2, AKT1

CD47 _ SIRPG

CD55 _ CD97, AKT1, CR1

HLA-C _ LILRA3

HLA-E _ KLRC1/2/4, SLC16A4, KIR2DL3/3DL2

HSP90AA1 _ NR3C1, CFTR, TGFBR1/2, AKT1, ITGB3, AHR, NOD2, RIPK1

IL32 _ PTGER1, MET

LAMB3 _ CD151, COL17A1, ITGA1/2/3/4/5/6/7/8/9/10/11/V, ITGB1/3/4/5/6/7/8, AKT1, PRNP

LAMC2 _ AKT1, ITGA1/2/3/4/5/6/7/8/9/10/11/V, ITGB1/3/4/5/6/7/8, COL17A1, PRNP, CD151

LGALS3BP _ VANGL1, ITGB1

LRPAP1 _ LDLR, VLDLR, SORL1, SORT1, LRP1/8

PLAUR _ ITGB3

Ileum only

Upregulated

219

BMP2 _ AMHR2, SMO, ACVR2A/R2B/R1/RL1, BMPR1A/1B/2, ENG, CDH11

BST2 _ LILRA4

CFLAR _ RIPK1

CSF1 _ PDGFRB, DDR2, LMTK2, TYRO3, RYK, MUSK, MET, CELSR3, SLC7A1, RET, ITGB3/AV, INSR, ALK, CSF1R/2RA/3R, ROR1, MSR1/T1R, NTRK1/2/3, MERTK, TIE1, AATK, AXL, ROR2, PTK7, LTK, PDGFRA, FLT3

CCL5 _CX3CR1, CCR1/2/3/4/5/6/7/8/9, CXCR1/2/3/4/5/6/10, ACKR1/2/4, GPR75, SDC1, ADRA2A, CD4, GRM7, XCR1

CX3CL1_CXCR1/2/3/4/5/6, CCR1/2/3/4/5/6/7/8/9/10, CX3CR1, XCR1

CXCL10_CXCR1/2, GRM7, CCR3/6/8

CXCL11_XCR1, CCR1/2/3/4/6/5/7/8/9/10, ACKR1, CX3CR1, CXCR1/2/3/4/5/6, ADRA2A, ACKR3

CXCL2 _ CCR3/6/8, ACKR1, CXCR1, CXCR2, GRM7

CXCL3 _ CCR3/6/8, CXCR1, CXCR2, GRM7

CXCL8 _ CCR1/2/3/4/5/6/7/8/9/10, SDC1/3, CX3CR1, ITGAM, CXCR1/2/3/4/5/6, XCR1, ACKR1, CDH5/79A, LPAR2, GRM7, ADRA2A,

EDN1 _ EDNRA/B, ADGRL4, AR, MCAM, NPR3, CYSLTR1/2, AKT1, ADCY9, KEL

EDN2_EDNRA/B, KEL

EFNA1 _ RET, INSR, ROR1, NTRK1/2, PDGFRB, TYRO3, MERTK, EPHA10, MST1R, ALK, RYK, AATK, AXL, DDR2, PTK7, LMTK2, CSF1R, FLT3, PDGFRA, NTRK3, LTK, TIE1, MUSK, ROR2, MET

IFNL1 _ IFNLR1

PLAU _ ITGA3/A5/AV/AM/B1/B5, VLDLR, MRC2, LRP1, IGF2R, ST14

TNF _ SLC5A11, TRPV1, PTPRU

TNFSF10 _ TNFRSF10B/C/D, RIPK1

TNFSF13B _ TNFRSF17/13B/13C

Ileum only

Downregulated

73

ANXA1 _ GRM7, GRIN2A

ARPC5 _ ADRB2, LDLR

B2M _ KIR2DL1/3DL1, AR

CALM1 _ CRHR1, SCN4A, TRPC3, GRM3/4/7, SCTR, PTH2R, KCNQ3, AQP6, MIP, GRIN2A, PLPP6, OPRM1; CALM2_PLPP6, TRPC3/V1, SCN4A, GRM7, AQP6, GRIN2A, KCNQ3

CALR _ ITGA2B/3/V, LRP1, SCARF1, PDIA3, AR, BDKRB2

CDH1 _ CDH2,

DSC2 _ DSG2

FAM3C _ CLEC2D

GRN _ SORT1

HLA-A _ KIR2DL1/2DL4/3DL3/3DL1, KLRC3

HLA-B _ KIR3DL3, KIR3DL1, KIR2DL1, KLRC3, KIR2DL4

HLA-C _ KIR2DL4/2DL1/3DL1/3DL3, KLRC3

HSP90B1 _ AR

LYZ _ ITGAL

MDK _ TSPAN1, SDC1/3, GPC2, ITGA4/6, PTPRB, ITGB1, LRP1, ALK

PSAP _ AR, GPR37/37L1

RTN4 _ RTN4RL1

SPTAN1 _ PTPRA

Colon and ileum

Upregulated

66

TNF_CD83/H11, F2RL1/F3, TNFRSF21, SPHK1, NR3C1, AKT1, TRADD, RIPK1, MYLK, INSR, PPARG, PIGR, GPR160, PTPRS, CELSR2

CXCL3 _ CXCR3/4/5/R1, CCR1/2/4/5/7/9/10, XCR1, ADRA2A

CXCL10 _ CX3CR1, CCR1/2/4/5/7/9/10, CXCR3/4/5/6, ADRA2A, XCR1

CXCL2_CXCR6 / CCR9 / CCR1 / CXCR5 / XCR1 CXCR3 / CXCR4 / CCR2 / CCR5 / CX3CR1 / ADRA2A / CCR4 / CCR7 / CCR10

ICAM1 _ ITGAX/L/M, IL2RG/RA, CDH5, CAV1

Colon and ileum

Downregulated

104

ADAM9 _ ITGA3/6/V, ITGB1/5

ANXA1 _ LMTK2, ADRA2A, FPR3, CCR10, DYSF

B2M _ PDIA3, KLRC1/2, KIR2DL3, LILRB2, HFE, CD247, IL2RA/RB/RG, CD1A/B, CD3G/D

CALM1 _ KCNQ1/5, PDE1B/C, MYLK, RYR1, INSR, VIPR1, GP6, PTPRA, GLP2R, KCNN4, ESR1/2

CALM2 _ KCNQ1/5, ESR1/2, TRPC1, MYLK, RYR1, PDE1B/C, INSR, GP6

CDH1 _ ITGAE/B7, LRP5/6, MET, KLRG1

HLA-A _ IL2RA, KIR2DL3/3DL2, KLRC1/2/4, LILRB2, IL2RB/RG, CD3G/D, APLP2

HLA-B _ KLRC1/2/4, CD3G/D, LILRB2, CANX, KIR2DL3/3DL2

HLA-C _ CD3G, KIR2DL3/3DL2, CD3D, KLRC1/2/4, LILRB2

HSP90B1 _ ASGR1, TLR1/2/4/7, LRP1

PI3 _ PLD2

PSAP _ CELSR1, LRP1, CD1B, SORT1

RTN4 _ NGFR, TNFRSF19, GJB2

S100A6 _ ESR1

SLPI _ CD4, PLSCR1/4

TIMP2 _ ITGA3, ITGB1

  1. Table listing the number of ligand–receptor interactions in infected immature enterocytes–immune cells intercellular network that are unique or shared between the ileal and colonic networks. The direction column indicates the direction of the expression change epithelial ligand driving each intercellular interaction. Interactions are indicated as follows: ligand_receptor1, receptor2, receptor3. Receptors belonging to the same class (e.g. calmodulins) are indicated as follows: CALM1/2/3.
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