Fig. 3: The effect of zonal expression of GSH and P450 on adverse outcome.
From: Unraveling the effect of intra- and intercellular processes on acetaminophen-induced liver injury
a Illustration of four different in silico zonation scenarios. Figure created with BioRender. b–d The dependence of the number of necrotic hepatocytes at 14 h after exposure (b), of the number of senescent hepatocytes at 48 h after exposure (c), and of the number of necrotic hepatocytes at 168 h (7 days) after exposure (d) on applied APAP concentration. Results are based on ten simulations per condition represented as mean ± sd.
