Fig. 1: Characterization of PBMC subpopulations in people living with HIV (PLWH) with (AS+) or without (AS−) atherosclerosis.
From: Executable models of immune signaling pathways in HIV-associated atherosclerosis
a t-SNE projection of 16 transcriptionally distinct cell subpopulations, shown in distinct colors. b Subpopulation-level differences in the percentage of sequenced cells corresponding to each cell type in panel ‘a’ between AS+ and AS− PLWH are identified using a t-test. The mean of each group is represented by a red asterisk. Panels c–f show the expression of genes that are differentially expressed (DE) between cells derived from AS+ and AS− subjects. DE genes were identified using the Wilcoxon test (Bonferroni-adjusted p-value < 0.1, absolute log2 fold change > 0.3.) DE genes in c CD8 T cells/NK resting cells, d monocytes, e naïve B cells referred to as “B cells naïve-2” in panels a, b, and f T cells referred to as “T cells CD8/CD4/CD4 naïve” in panels a, b.
