Fig. 6: Monocyte states with respect to the leukocyte transendothelial migration pathway identified by attractor analysis with scBONITA.
From: Executable models of immune signaling pathways in HIV-associated atherosclerosis
a UMAP representation of the cluster of monocytes colored by the attractor to which they are assigned, based on their similarity. The two dominant modes (F11R+ and PECAM+ attractors) are represented by blue and orange. All other attractors are collectively labeled in gray. b Percentages of monocytes derived from each subject, mapping to the two dominant attractors and all other attractors for the leukocyte transendothelial migration pathway. c Attractor gene values for the leukocyte transendothelial migration pathway trained on monocytes, ranging from 0 (blue) to 1 (red), averaged for each individual subject. The top bar indicates AS+ (gray) and AS− (black) subjects. The genes that differ between the two dominant attractors F11R+ and PECAM+ are highlighted by a violet box.
