Fig. 3: Environmental valine is differentially essential in clinical isolate context-specific models of K. pneumoniae. | npj Systems Biology and Applications

Fig. 3: Environmental valine is differentially essential in clinical isolate context-specific models of K. pneumoniae.

From: Genome-scale metabolic modeling reveals increased reliance on valine catabolism in clinical isolates of Klebsiella pneumoniae

Fig. 3

A Reaction topology differentially present between the context-specific model groups. B Differential reaction essentiality between isolate model groups, essentiality was determined through single reaction knockout screen with a cutoff of 1% of the biomass flux. Inclusion in final analysis was determined by cross reference against uncontextualized GENRE and a within-group shared threshold of >55% of models possessing a given feature. Color within the figure area indicates essentiality/presence (red) and non-essentiality/absence (blue), and color on the top margin denotes strain-type of origin for the associated transcriptome with clinical isolate (purple) or laboratory strain (teal).

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