Fig. 1: Simulation results at ion channel and cellular levels. | npj Systems Biology and Applications

Fig. 1: Simulation results at ion channel and cellular levels.

From: Computational analysis of arrhythmogenesis in KCNH2 T618I mutation-associated short QT syndrome and the pharmacological effects of quinidine and sotalol

Fig. 1

A The fitted current–voltage (I–V) curves in wild-type (black) and T618I (red) conditions using IKr Markov chain models. Experimental data from Sun et al.11 (their Fig. 4B). Error bars represent the standard error of measurement (SEM). B The IKr Markov chain model. C Steady-state (1.25 Hz) action potentials (Ci) and the corresponding IKr (Cii) for EPI cells. Solid and dashed lines represent wild-type and T618I conditions, respectively. D Steady-state action potentials and the corresponding IKr for MIDDLE cells. E Steady-state action potentials and the corresponding IKr for ENDO cells. F The comparison of the peak IKr in wild-type and T618I conditions. G The comparison of transmural APD differences. H The comparison of transmural ERP differences.

Back to article page