Fig. 10: Simulation results of the reentry arrhythmias in the condition of quinidine. | npj Systems Biology and Applications

Fig. 10: Simulation results of the reentry arrhythmias in the condition of quinidine.

From: Computational analysis of arrhythmogenesis in KCNH2 T618I mutation-associated short QT syndrome and the pharmacological effects of quinidine and sotalol

Fig. 10

A Spiral waves on the 2D ventricular slice. Spiral waves were evoked by the S1–S2 protocol, and the black arrow indicates the stimulating location of S2. Quinidine prevented the persistent arrhythmias, which was evidenced by the disappearance of spiral waves at about 1000 ms. B Scroll waves in the 3D ventricle. In line with the 2D simulation results, the evoked scroll waves were not sustainable and disappeared at about 900 ms.

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