Fig. 9: Simulation results of APD and CV restitution curves and the rate adaption curves of QT interval under wild-type, T618I mutation, and quinidine conditions. | npj Systems Biology and Applications

Fig. 9: Simulation results of APD and CV restitution curves and the rate adaption curves of QT interval under wild-type, T618I mutation, and quinidine conditions.

From: Computational analysis of arrhythmogenesis in KCNH2 T618I mutation-associated short QT syndrome and the pharmacological effects of quinidine and sotalol

Fig. 9

A APD restitution curves obtained from the S1–S2 protocol (Ai) and the dynamic protocol (Aii), where APDs were plotted against PCL and DI, respectively. B CV restitution curves obtained from the S1–S2 protocol (Bi) and the dynamic protocol (Bii). C The rate adaption curves of QT interval.

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