Fig. 3: Relationships between diseases and their approved drugs.
From: Regulome-based characterization of drug activity across the human diseasome
a Distribution of correlation scores between transcriptome-based drug and disease signatures. b Distribution of correlation scores between regulome-based drug and disease signatures. Each boxplot represents correlation scores of the drugs approved for the corresponding disease. The horizontal axis indicates the list of diseases and the vertical axis indicates cosine correlation coefficient. Diseases are listed in order of increasing median correlation scores. In the box plots: center line, median; box, interquartile range; whiskers, 1.5× interquartile range; dots, outliers. c Radial plot of enrichment scores for transcription factors in the regulome signature of nasopharyngeal cancer. d Radial plot of enrichment scores for transcription factors in the regulome signature of approved drugs for nasopharyngeal cancer. e Radial plot of enrichment scores for transcription factors in the regulome signature of primary open angle glaucoma. f Radial plot of enrichment scores for transcription factors in the regulome signature of approved drugs for primary open angle glaucoma.
