Fig. 4: Effect of gene expression alterations on flux predictions in HD.
From: Fluxomics reveals cellular and molecular basis of increased renal ammoniagenesis
A Pearson correlation coefficients between measured and predicted exchange fluxes. The objective in all simulations in this figure is ammonia. The reactions on the x axis—SHM, FBP, etc.—represents the effect of overexpression of the respective genes on the predicted fluxes and the resulting Pearson correlation with the measured exchange fluxes. The asterisk * indicates significance. B Relative changes in predicted fluxes (%) for activity of SHM and AMT genes in all pathways. Boxplots show the gene expression levels of significantly altered genes in the rat.
