Fig. 1: Workflow of method.
From: Deduction of signaling mechanisms from cellular responses to multiple cues
For each mechanism of (i) regulation, (ii) molecular conversion, or (iii) reversible binding, we start with the minimal possible network in terms of both nodes and edges and evaluate whether the network can explain the cell behavior. If the minimal network cannot explain the observed behavior we increase the complexity of the network by increasing the number of nodes or edges, one at a time, and we evaluate the new network. We repeat until the minimal successful network is identified.
