Fig. 3: Mathematical modeling.
From: Deduction of signaling mechanisms from cellular responses to multiple cues
For networks containing one of three possible types of interaction, a regulation, b molecular conversion, or c reversible binding, we model the dynamics using deterministic rate equations, as shown. For each network we calculate the steady state m(s1, s2), which determines how the output M changes with the inputs S1, S2. To focus on network topology, we set rates (the ki) and conserved quantities (like a0) to 1 when assessing whether value antagonism or slope antagonism is achieved.
