Fig. 4: Partial validation of the model against REGEN-COV antibody cocktail trial data. | npj Systems Biology and Applications

Fig. 4: Partial validation of the model against REGEN-COV antibody cocktail trial data.

From: A quantitative systems pharmacology model of the pathophysiology and treatment of COVID-19 predicts optimal timing of pharmacological interventions

Fig. 4

A–D Time course of the viral dynamics of the overall virtual population and each of the subgroups compared against observations from the REGEN-COV Ph2 clinical trial for the placebo group and the 8 g REGEN-COV treatment group. Error bars are representative of the standard error for the virtual population and clinical trial observations. E Log10 reduction in viral load from baseline at day 5 for the overall virtual population and each of the subgroups compared against observations from the REGEN-COV Ph2 clinical trial for the placebo group and the 8 g REGEN-COV treatment group. Error bars are representative of the 99% prediction interval of the mean for the virtual population. F Log10 reduction in viral load from baseline at day 5 for the overall virtual population compared against observations from the Ph3 trial REGEN-COV trial for the 2.4 g REGEN-COV treatment. Error bars are representative of the 95% confidence interval for clinical trial observations. Violin plots are indicative of 99% prediction interval of mean from 1000 bootstrapped samples of the virtual population. REGEN-COV Ph2 data extracted from 24 and REGEN-COV Ph3 data extracted from ref. 39.

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