Fig. 1: Network approach used to identify the potential co-drug candidate for Metformin.
From: Identification of Probucol as a candidate for combination therapy with Metformin for Type 2 diabetes
a Drug-target bipartite network of the shortlisted drugs and their targets in the FPS. b Drugs were ranked based on the number of known targets captured by the FPS and further filtered based on literature and mechanism of action. c Sub-bipartite network of Probucol, Metformin, and their targets. Probucol was shortlisted as the potential co-drug, and a sub-bipartite network of Probucol, Metformin, and their targets was generated from the parent bipartite network. Metformin is represented in red, Probucol in yellow, blue nodes represent target genes in the FPS, and the top 5 KEGG pathways (based on p-value (Fisher’s exact test)) in which the genes are enriched are indicated.
