Fig. 3: Histopathological analysis of pancreatic tissue.
From: Identification of Probucol as a candidate for combination therapy with Metformin for Type 2 diabetes
Tissue was obtained from NAD-STZ induced diabetic model (400x; scale bars = 25 µm). All analyses were performed in duplicates (1, 2). The sections studied showed pancreatic lobules separated by connective tissue septa. The center of islet cells consists of Beta-cells (Long-arrow), while the periphery comprises large Alpha-cells (Short-arrow) with intervening vascular spaces. The pancreatic lobules consist largely of the exocrine acini and their intralobular ducts. Most of the lobules show small, round, light-staining islets of Langerhans. a, b Controls – Normal and Diabetic. Some of the beta cells show degenerative changes in the positive control. c, d Individual drug treatment - Metformin and Probucol treated. e Drug combination M + P (5:0.5). f M + P (2.5:0.5). g M + P (2.5:0.25). Dose I [M + P (5:0.5)] restored the condition of cells closest to that of the normal tissue conditions. See also Supplementary Fig. 2.
