Fig. 3: Fitting with biomarker (LDH) data.
From: Effective dose window for containing tumor burden under tolerable level
The circles indicate the data points for each patient and the solid line shows the model-predicted dynamics of the LDH level in international units per liter (IU/L). FIM: Fisher information matrix. It should be noted that the second and fourth data points in the case of Patients five and eight, respectively, were excluded while fitting, as these two instances resemble deviations from the regular trend observed through the other data points, which could be a consequence of other physical problems. Owing to the lack of detail in the patient’s history, we proceed with this assumption.
