Fig. 4: Dose modulates the basin of attraction.
From: Effective dose window for containing tumor burden under tolerable level
The triangular region shows the phase space for patient 2. The initial cell composition is shown by the gray diamond (◇). The solid orange line shows the R-nullcline (equation (3)), which is invariant to δ, and the solid orange circle represents the R-only equilibrium. The dotted blue line shows the S-nullcline (equation (2)) with the MTD, and the empty blue circle is the unstable S-only equilibrium. The dotted purple line shows the S-nullcline (equation (2)) with 70% of the MTD (belonging to the EDW (equation (4))), and the filled purple circle is the stable S-only equilibrium. The solid black line indicates the separatrix. The two arrows indicate the direction in which the separatrix and S-nullcline are shifted when δ decreases.
