Fig. 9: Doses adjusted to tolerable tumor burden.
From: Effective dose window for containing tumor burden under tolerable level
Effective dose window (the shaded gray region) is bounded by the upper horizontal (determined by the competition coefficient) and the lower inclined black line (the minimum effective dose). The vertical blue lines show the effective dose window for adaptive therapy for different TTV adopted from Supplementary Fig. 5. The orange asterisk indicates an optimal dose, which coincides with the lower bound of the effective dose window. The vertical dashed line resembles the threshold value of Ktol below which the tumor cannot be contained.
