Fig. 1: Schematic of IL-6 signaling network.

IL-6 classic and trans-signaling is induced by IL-6 binding to membrane-bound and soluble IL-6 receptors, respectively, and recruiting gp130, which activates PI3K/Akt, MAPK, and STAT3 pathways and phosphorylates Akt, ERK, and STAT3, respectively.