Fig. 2: Model comparison to training and validation data for IL-6 stimulation. | npj Systems Biology and Applications

Fig. 2: Model comparison to training and validation data for IL-6 stimulation.

From: Experiment-based computational model predicts that IL-6 classic and trans-signaling exhibit similar potency in inducing downstream signaling in endothelial cells

Fig. 2

50 ng/ml IL-6 with or without additional 100 ng/ml sIL-6R induced relative pSTAT3 (A), ppAkt (B), and pERK (C). Varying concentrations of IL-6 alone induced relative pSTAT3 (D) and with additional 100 ng/ml sIL-6R induced relative pSTAT3 (E). The circles are experimental data. Bars are mean ± SEM. Curves are the mean values of the 12 best fits. Shaded regions show 95% confidence intervals of the fits. Dashed and solid curves are training and validation results, respectively. Light gray: 50 ng/ml IL-6 (A–C), 0–50 ng/ml IL-6 (D), and 10 ng/ml IL-6 (F–H) stimulation; Dark gray: 50 ng/ml IL-6 + 100 ng/ml sIL-6R (A–C), 0–50 ng/ml IL-6 + 100 ng/ml sIL-6R (E), and 10 ng/ml IL-6 + 10 ng/ml sIL-6R (F–H).

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