Fig. 3: Predicted maximum pSTAT3, pAkt, and pERK responses. | npj Systems Biology and Applications

Fig. 3: Predicted maximum pSTAT3, pAkt, and pERK responses.

From: Experiment-based computational model predicts that IL-6 classic and trans-signaling exhibit similar potency in inducing downstream signaling in endothelial cells

Fig. 3

Maximum pSTAT3 (A), pAkt (B), and pERK (C) in response to IL-6 concentrations varying from 0 to 5 nM without sIL-6R. In the absence of IL-6R, 2 nM IL-6 in combination with sIL-6R concentrations varying from 0 to 100 nM induced maximum pSTAT3 (D), pAkt (E), and pERK (F). Curves are the mean values of the 12 best fits. Shaded regions show 95% confidence intervals of the fits. Orange: classic signaling responses; Yellow: trans-signaling responses.

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