Table 1 Predicted maximum pSTAT3, pAkt, and pERK responses for the baseline model, the modified model when IL-6R was set as a constant input, when kinetic rates governing R1 and R2 to be the same as the corresponding kinetic rates for R3 and R4, and when both IL-6R was set as a constant input and kinetic rates governing R1 and R2 to be the same as the corresponding kinetic rates for R3 and R4.

From: Experiment-based computational model predicts that IL-6 classic and trans-signaling exhibit similar potency in inducing downstream signaling in endothelial cells