Fig. 8: Heterogeneity of drug screening simulations.

a shows the growth curves for the no-drug simulation and the drug simulation with Ipatasertib (IC50) and Pictilisib (IC90) separated into sphere layers. By taking the distance to the tumour centre, we define five 50 μm-thick spherical layers: layer one is the innermost layer and layer five corresponds to a distance from 200 to 250 μm from the tumour centre. From these growth curves, the AUC values and growth indices are calculated for each layer separately. b shows a 3D representation of the cell population growth indices of the five 50 μm-thick spherical layers at the end of the simulation. Layer 1 is the innermost layer from the centre of the tumour to a distance of 50 μm from the centre. Blue cells are living cells and Red cells are apoptotic.