Fig. 3: Signal flow paths to fixed points. | npj Systems Biology and Applications

Fig. 3: Signal flow paths to fixed points.

From: Modulating the dynamics of NFκB and PI3K enhances the ensemble-level TNFR1 signaling mediated apoptotic response

Fig. 3

Absorption of the initial state \({\bar{{\boldsymbol{v}}}}_{0}\) into two fixed points via distinct signal flow paths. The order in which the Boolean values of the entities are placed in a state is housekeeping (H), input (I), signaling (S) and output (O) nodes. Entities corresponding to the underlined values are pLSSA-fixed nodes. Blue arrows indicate one-step transitions with a certain permutation using ROA. Permutation used are in Supplementary Note 2.2.

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