Fig. 8: Effect of Comp1 – IKK* inhibition on intracellular signaling entities. | npj Systems Biology and Applications

Fig. 8: Effect of Comp1 – IKK* inhibition on intracellular signaling entities.

From: Modulating the dynamics of NFκB and PI3K enhances the ensemble-level TNFR1 signaling mediated apoptotic response

Fig. 8

Relative change of the transients of A \({\rm{NF}}{{\kappa }}{\rm{B}}\), B \({\rm{I}}{{\kappa }}{{\rm{B}}}^{* }\), C Bax, D XIAP and D \({\rm{c}}{3}^{* }-{\rm{p}}17\) being active for the case of TNFR1 network with inactive \({\rm{Comp}}1-{\rm{IK}}{{\rm{K}}}^{* }\). Relative change is quantified by \({{\Delta }}{\mathbb{E}}(t)=\left(\right.{{\mathbb{E}}}^{{\rm{TNFR}}{1}^{\Delta}}\left({\rm{t}}\right)-{{\mathbb{E}}}^{{\rm{TNFR}}1}\left({\rm{t}}\right)\))/\(\,{{\mathbb{E}}}^{{\rm{TNFR}}1}\left({\rm{t}}\right)\). Pink cloud around the population-averaged trajectory (red) encompasses the \({{\Delta }}{\mathbb{E}}\) from different start states. Blue dashed line captures the trajectory for each of the nodes from the same randomly chosen start state. Inset in B captures the zoomed version of a part of the figure for better clarity.

Back to article page