Fig. 3: CD4 and CD8 T cells become more divergent following TCR stimulation. | npj Systems Biology and Applications

Fig. 3: CD4 and CD8 T cells become more divergent following TCR stimulation.

From: Integrative temporal multi-omics reveals uncoupling of transcriptome and proteome during human T cell activation

Fig. 3

a Stacked bar graphs showing the total number of proteins and mRNA transcripts DE between CD4 and CD8 T cells at each time point. Columns represent transcripts and proteins overexpressed in each T cell subset. b Volcano plots showing proteins mRNA DE between CD4 and CD8 T cells at 0 h. Names of the top 10 overexpressed mRNA and proteins in CD8 and CD4 T cells are indicated. c Expression kinetics of proteins upregulated in CD4 (i) and CD8 (ii) T cells and their corresponding mRNA transcripts. Intensities of each time point are shown as mean and the standard error of the mean (SEM) error bars (n = 3). d Heatmap shows the relationship of protein/mRNA expression between DE CD4 and CD8 T cells over the time course. mRNA and protein commonly quantified between two T cell subsets were used. Average linkage and Pearson distance measurement were used in column clustering. The clusters of mRNA transcripts and proteins are indicated by distinct colors.

Back to article page