Fig. 1: Overview of the main study. | npj Systems Biology and Applications

Fig. 1: Overview of the main study.

From: Logic programming-based Minimal Cut Sets reveal consortium-level therapeutic targets for chronic wound infections

Fig. 1

MCSs of size three or less are denoted as small-size MCSs. a Performance of MCSs computation tools on the S. aureus and P. aeruginosa consortium model is tested with consortium-lethal MCSs. b Small-size MCSs are computed on single-species models, then tested for growth recovery on the consortium-level model. c For MCSs which are no longer lethal on the consortium model, larger size consortium MCSs are computed, revealing metabolite exchanges. d For MCSs that are still lethal on the consortium retrieved in both bacteria, interspecies protein structure alignments of AlphaFold structures are performed, and the best drug targets for therapeutic intervention in human are retrieved.

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