Fig. 4: Consortium MCSs estimated to be targetable with a single ligand. | npj Systems Biology and Applications

Fig. 4: Consortium MCSs estimated to be targetable with a single ligand.

From: Logic programming-based Minimal Cut Sets reveal consortium-level therapeutic targets for chronic wound infections

Fig. 4

Only P. aeruginosa and S. aureus targets whose protein structures matched best were kept. a Ordinates labels show targetable enzymes. Bars heights are Root Mean Square Deviation (RMSD) of atom positions, measured in Ångström, resulting from protein structural alignment of enzyme pairs. Enzymes indicated with ‘H’ were found to have human homologues. b Pie distribution for associated metabolism groups for each targetable enzyme in a. c Pie distribution of categories of MCSs potentially targetable in human. From the 23 MCSs targetable in human (in c), only 12 are independent of the growth medium (shown in a and b).

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