Fig. 8: Cell lines, where HR pathway perturbation resulted in synergy and viability decrease had mutations entangled to the WNT pathway. | npj Systems Biology and Applications

Fig. 8: Cell lines, where HR pathway perturbation resulted in synergy and viability decrease had mutations entangled to the WNT pathway.

From: Network-driven cancer cell avatars for combination discovery and biomarker identification for DNA damage response inhibitors

Fig. 8

Mutations of cell lines that decreased their viability after artificial perturbations mimicking overexpression and gain-of-function mutations of HR pathway members had a common, intrinsic WNT pathway entanglement. These mutant WNT pathway genes caused the overactivation of the WNT pathway, which is known to be a potential resistance mechanism to PARP inhibition. Gain-of-function mutations appeared in proteins important in activating the WNT pathway, while loss-of-function mutations tended to be appearing in negative regulators of the WNT pathway.

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