Fig. 4: SignalingProfiler 2.0 network generation parameters tuning (Step 2).
From: SignalingProfiler 2.0 a network-based approach to bridge multi-omics data to phenotypic hallmarks
Violin plots reporting the impact of Ser/Thr Kinome Atlas integration in the prior knowledge network, number of layers in the naïve network, and CARNIVAL flavors and types on Precision and Recall with respect to the gold standard and on the number of interactions validated with phosphoproteomics data, across 2989 generated models. The black line indicates the average y value. Statistical significance was computed with T-test statistical analysis (*p-value < 0.05, **<0.01, ***<0.001, ****<0.0001).
